Welcome to the Mayo Laboratory
Computational Protein Design
The focus of the lab is the coupling of theoretical, computational, and experimental techniques for the study of structural biology. In particular, we have placed a major emphasis on developing quantitative methods for protein design with the goal of developing a fully systematic design strategy that we call "protein design automation." Our design approach has been refined and captured in a software program called TRIAD and has been applied to a variety of problems ranging from antibody engineering to the creation of de novo enzymes.